Table 3.
Aberrant expression of miRNAs in fluids or blood cells of PD patients.
| Studies | Sources | PD, n | Ctrl, n | Method | Increased miRNA | Decreased miRNA |
|---|---|---|---|---|---|---|
| Margis et al., 2011 | Blood | 81 | 8 | qPCR | miR-1, miR-22∗, miR-29a | |
| Serafin et al., 2015 | Blood | 36 | 36 | qPCR | miR-29a, miR-30b, miR-103a | |
| Soreq et al., 2013 | Leukocytes | 7 | 6 | NGS | miR-18b∗, miR-20a, miR-21, miR-150, miR-199b, miR-378c, miR-671, miR-1249, miR-1274b, miR-4293 | miR-16, miR-92b, miR-320a, miR-320b, miR-320c, miR-769 |
| Martins et al., 2011 | PBMCs | 19 | 13 | M-array | miR-19b, miR-26a, miR-28-5p, miR-29b, miR-29c, miR-30b, miR-30c, miR-126, miR-126∗, miR-147, miR-151-3p, miR-151-5p, miR-199a-5p, miR-199a/b-3p, miR-301a, miR-335, miR-374a, miR-374b | |
| Cardo et al., 2013 | Plasma | 31 | 25 | qPCR/TLDA2 | miR-331-5p | |
| Khoo et al., 2012 | Plasma | 42 | 30 | qPCR/M-array2 | miR-222, miR-505, miR-626 | |
| Li et al., 2017 | Plasma | 60 | 60 | qPCR | miR-137 | miR-124 |
| Current study, 2017 | Plasma | 46 | 49 | qPCR | miR-133b, miR-433 | |
| Burgos et al., 2014 | Serum | 50 | 62 | NGS | miR-30a-3p, miR-30e-3p, miR-338-3p | miR-16-2-3p, miR-1294 |
| Botta-Orfila et al., 2014 | Serum | 65 | 65 | TLDA | miR-19b, miR-29a, miR-29c | |
| Cao et al., 2017 | Serum | 109 | 40 | qPCR | miR-24, miR-195 | miR-19b |
| Ding et al., 2016 | Serum | 106 | 91 | qPCR/S-seq2 | miR-195 | miR-15b, miR-181a, miR-185, miR-221 |
| Dong et al., 2016 | Serum | 122 | 104 | qPCR/S-seq2 | miR-141, miR-146b-5p, miR-193a-3p, miR-214 | |
| Ma et al., 2016 | Serum | 138 | 112 | qPCR | miR-29c, miR-146a, miR-214, miR-221 | |
| Vallelunga et al., 2014 | Serum | 25 | 25 | qPCR/TLDA2 | miR-24, miR-223∗, miR-324-3p | miR-30c, miR-148b |
| Zhao et al., 2014 | Serum | 46 | 46 | qPCR | miR-133b | |
| Burgos et al., 2014 | CSF | 57 | 65 | NGS | miR-19a-3p, miR-19b-3p, let-7g-3p | miR-10a-5p, miR-127-3p, miR-128, miR-132-5p, miR-136-3p, miR-212-3p, miR-370, miR-409-3p, miR-431-3p, miR-433, miR-485-5p, miR-873-3p, miR-1224-5p, miR-4448 |
| Gui et al., 2015 | CSF | 78 | 35 | qPCR/TLDA2 | miR-10a-5p, miR-136-3p, miR-153, miR-409-3p, miR-433, let-7g-3p | miR-1, miR-19b-3p |
| Marques et al., 2016 | CSF | 28 | 28 | qPCR | miR-205 | miR-24 |
CSF, cerebrospinal fluid; Ctrl, controls; M-array, microarray; NGS, next generation sequencing; PBMCs, peripheral blood mononuclear cells; PD, Parkinson’s disease; S-seq, Solexa sequencing; TLDA, TaqMan Low Density Array; 1Untreated PD patients; 2qPCR as validation after initial screening using array or sequencing.