Table 1.

Effect of hyperoxia on GSH reductase activity, and on GSH and GSSG content in TIIcells

	Control	Hyperoxia
GSH reductase (% of control)	100	76 ± 10*
GSH (μmol/mg protein)	0.022 ± 0.015	0.020 ± 0.008
GSSG (μmol/mg protein)	0.005 ± 0.0015	0.013 ± 0.001*
GSH/(GSH+GSSG) (ratio)	0.81	0.61

Activity of glutathione (GSH) reductase and concentration of GSH and GSSG were determined in freshly prepared TIIcells of rats exposed to air (control) or oxygen for 48 hrs (hyperoxia) as described in Materials and Methods. Values are means ± standard deviation of n = 3 independent experiments. Asterisk indicates a significant difference to control (p < 0.05).