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. 2005 Jan 17;6(1):7. doi: 10.1186/1465-9921-6-7

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Copyright © 2005 Wang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of Cl^-conductance agonists on TEP: Applying Fsk (5 μM)+IBMX (100 μM), adenosine (100 μM), ATP (100 μM) and ATP (100 μM)+adenosine (100 μM) to the perfusate to activate CFTR gCl^-in the presence of a hyperpolarizing Cl^-gradient, the TEP hyperpolarized significantly; however, the response appeared to be increased when both ATP and adenosine were added together. In order to observe maximum effect on activation of Cl^-conductance, amiloride (10 μM) is present in all luminal perfusate above to block Na⁺conductance.