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. 2017 Jun 22;7:4092. doi: 10.1038/s41598-017-04460-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HUVEC enhanced DRG axonal growth is cell type specific. DRG explants cultured on (A) poly-D-lysine (PDL) coated wells, (B) myoblasts, and (C) HUVECs. PDL and myoblast coatings facilitated axonal growth that was radially symmetrical while HUVEC co-cultures facilitated asymmetric growth towards clusters of HUVECs (arrows). Scale = 200 µm. (D) Quantification of axonal growth from DRG explants on different surfaces. Low density of HUVECs supported the most axonal outgrowth of all treatment groups. Data are presented as mean ± standard error. *(p < 0.05), **(p < 0.01), ***(p < 0.001) and brackets indicate significance from other surfaces as determined by one-way ANOVA with Holm-Sidak post hoc analysis (DRG sample size for each group shown in bars from 3 independent replicates).