Table 2.
Association results for the selected important variants.
| CHR | SNP | BP | A1 | Freq. | OR | L95 | U95 | P | Reported gene (aa_change) | Gout or SU |
|---|---|---|---|---|---|---|---|---|---|---|
| 2 | rs1260326 | 27,730,940 | C | 0.378/0.456 | 0.698 | 0.576 | 0.845 | 2.23E-04 | GCKR (L446P) | Gout, SU |
| 2 | rs2307394 | 148,716,428 | T | 0.443/0.457 | 0.918 | 0.762 | 1.104 | 0.3628 | ORC4 (A78S) | SU |
| 4 | rs16890979 | 9,922,167 | T | 0.011/0.017 | 0.542 | 0.229 | 1.285 | 0.1644 | SLC2A9 (V253I) | Gout, SU |
| 4 | rs3775948 | 9,995,182 | G | 0.322/0.402 | 0.738 | 0.604 | 0.903 | 3.09E-03 | SLC2A9 | Gout, SU |
| 4 | rs2231142 | 89,052,323 | T | 0.496/0.309 | 1.837 | 1.519 | 2.222 | 3.83E-10 | ABCG2 (Q141K) | Gout, SU |
| 4 | rs72552713 | 89,052,957 | A | 0.009/0.005 | 1.404 | 0.5316 | 3.707 | 0.4936 | ABCG2 (Q126X) | Gout, SU |
| 6 | rs11754288 | 25,776,949 | A | 0.155/0.184 | 0.582 | 0.443 | 0.764 | 9.58E-05 | SLC17A4 (A318T) | SU |
| 6 | rs1165196 | 25,813,150 | G | 0.168/0.203 | 0.570 | 0.441 | 0.738 | 1.94E-05 | SLC17A1 (I269T) | SU |
| 11 | rs4073582 | 66,050,712 | A | 0.013/0.020 | 0.431 | 0.198 | 0.938 | 0.0339 | CNIH2 | Gout |
| 12 | rs671 | 112,241,766 | A | 0.116/0.153 | 0.684 | 0.519 | 0.900 | 6.80E-03 | ALDH2 (E504K) | Gout |
CHR, Chromosome; SNP, dbSNP rs number; BP, Position, based on hg19; A1, minor allele for the whole sample; Freq., frequency of A1 for cases/controls; OR, odds ratio, for A1; L95, the lower endpoint of the 95% confidence interval (CI); U95, the upper endpoint of the 95% confidence interval; P, p value. Reported gene(s), The reported gene(s) in the previous GWAS; aa_change, amino acid change; Gout or SU, indicating whether the locus found to be associated with gout or SU; The variants with p < 0.05 were indicated in bold. All the OR (95% CI) and p values reported in this study were based on the PCA adjustment analysis.