Table 2.
Variables (units) | Plasma | Ileum fluid |
---|---|---|
Cmax (μg/mL) | 0.03 ± 0.03 | 23.66 ± 0.92 |
Tmax (h) | 2.41 ± 1.32 | 1.96 ± 0.03 |
T1/2 λz (h) | 3.61 ± 1.87 | 5.86 ± 0.71 |
AUC0–last (μg ∙ h/mL) | 0.22 ± 0.16 | 106.40 ± 12.68 |
AUC0–∞ (μg ∙ h/mL) | 0.26 ± 0.21 | 112.35 ± 14.07 |
AUMC0–last (μg ∙ h2/mL) | 1.14 ± 0.42 | 568.49 ± 110.27 |
AUMC0–∞(μg ∙ h2/mL) | 1.86 ± 0.92 | 743.23 ± 165.71 |
MRT0–last (h) | 5.19 ± 3.21 | 5.34 ± 0.39 |
Notes: The pharmacokinetic parameters were calculated by non-compartment model.