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. 2017 Jun 22;7:4041. doi: 10.1038/s41598-017-04151-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of ROI uncertainties to the texture features. The delineated glioma in a slice near the left lateral ventricle in a 73 year old male, from which the variations in the texture features were calculated in Table 1. The colormap shows the ADC map, fused on the T1-weighted contrast enhanced MPRAGE. An expansion or a shift by one voxel can include CSF in the ROI, which will increase the minimum and maximum values in the ROI, and will have an effect on the resulting texture features. The manual quantization method is less sensitive to this shift.