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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Dec 22;140(3):663–670. doi: 10.1016/j.jaci.2016.10.042

Figure 2. Angpt-Tie2 pathway mediates endothelial barrier function in response to inflammatory stressors.

Figure 2

(A) Schematic of Tie2-dependent barrier defense pathway in endothelium. (B–C) Vascular permeability measurements from lungs of mice treated with LPS with and without Angpt-1 demonstrating enhanced susceptibility to vascular leakage arising from incomplete loss of expression of either Tie2 (receptor for Angpt-1) (B) or p47Phox (C). Results are normalized to respective genetic controls to illuminate differences in responses to LPS. ****p<0.0001, 2-way ANOVA. Adapted from References65, 66, 84.