Table 5.
Cox Regression Models of Chronic Antibody Mediated Rejection in Different Patients Groups
| All Patients | ||||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| Variables | HR (CI) | p-value | HR (CI) | p-value |
| Early Acute clinical AMR | 4.1(1.6-8.6) | p<0.01 | 1.3(0.5-3.0) | p=0.6 |
| Acute cellular rejection | 3.0(2.1-4.4) | P<0.01 | 2.3(1.5-3.4) | P<0.01 |
| cPRA ≥80% | 3.8 (2.5-5.7) | p<0.01 | 1.6(0.9-2.7) | p=0.12 |
| Class I DSA only | 2.6(1.3-4.5) | p<0.01 | 0.9(0.4-2.3) | p=0.98 |
| Class II DSA only | 3.5(2.2-5.6) | p<0.01 | 1.5(0.7-3.5) | p=0.29 |
| Class I + II DSA | 6.4(2.9-12.3) | p<0.01 | 1.5(0.4-4.4) | p=0.50 |
| Sum all DSA* | 1.8(1.6-2.1) | p<0.01 | 1.1 (0.8-1.5) | p=0.43 |
| +DSA/-XM | 1.4 (0.7-2.6) | p=0.35 | ||
| +DSA/low+XM | 3.7 (1.8-6.5) | p<0.01 | 2.3(0.9-5.7) | p=0.07 |
| +DSA/high+XM | 7.3 (4.5-11.5) | p<0.01 | 2.8(1.1-7.4) | p=0.03 |
| -DSA/+XM | 1.5 (0.5-3.6) | p=0.44 | ||
| Full model | p<0.01 | |||
| Patients with DSA detected at the time of transplant (+DSA/-XM, +DSA/low+XM, +DSA/high+XM) | ||||
| Univariate | Multivariate | |||
| Variables | HR (CI) | p-value | HR (CI) | p-value |
| Early Acute clinical AMR | 1.7(0.4-4.8) | p=0.40 | ||
| Acute cellular rejection | 1.3(0.7-2.5) | P=0.40 | ||
| cPRA ≥80% | 1.7(0.9-3.2) | p=0.09 | ||
| Class I DSA only | 0.7(0.4-1.4) | p=0.33 | ||
| Class II DSA only | 1.0(0.6-1.9) | p=0.99 | ||
| Class I+II DSA only | 2.2(0.9-4.4) | p=0.07 | ||
| Sum MFI all DSA | 1.5(1.2-1.8) | p<0.001 | ||
| Patients with no DSA detected at time of transplant (-DSA/-XM and −DSA/+XM) | ||||
| Univariate | Multivariate | |||
| Variables | HR (CI) | p-value | HR (CI) | p-value |
| Early Acute clinical AMR | 4.8(1.2-12.9) | p=0.03 | 2.1(0.5-6.0) | p=0.26 |
| Acute cellular rejection | 3.9(2.4-6.3) | P<0.01 | 3.6(2.2-5.8) | P<0.01 |
| Number of HLA mismatches | 1.2(1.0-1.4) | P=0.01 | 1.3(1.1-1.5) | P<0.01 |
| cPRA ≥80% | 3.1(1.5-5.7) | p<0.01 | 4.5(2.1-8.7) | p<0.01 |
| Full model | p<0.01 | |||