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. 2017 Jun 15;10(4):958–968. doi: 10.1111/1751-7915.12736

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© 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proposed model of the sorbicillin biosynthetic pathway and its regulation.

A. PKS domains in SorA and SorB are abbreviated as KS (ketosynthase), ACP (acyl carrier protein), KR (ketoreductase), DH (dehydratase), MT (methyltransferase), ER (enoylreductase). Adapted from Ref. (Avramović, 2011; Fahad et al., 2014; Derntl et al., 2016; Salo et al., 2016).

B. The autoinduction mechanism of pathway gene expression by sorbicillinoids which involves the two transcriptional factors SorR1 and SorR2. On top, a schematic representation of the gene cluster. Black solid arrows indicate a positive stimulation and the red arrows show a negative effect. Green arrows represent the promoters of the indicated genes.