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. 2017 Jun 14;10(4):926–932. doi: 10.1111/1751-7915.12603

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© 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The structure of breast cell line cancer MDA‐DB 231 before treated with a crude mycelia extract of N. sphaerica (A1) and a crude leaf extract of C. roseus (B1). After 72 h treated with different concentrations of vinblastine produced by both crude extracts, the structure of breast cell line changed from a rod shape into round shape (red circle). The breast cell line cancer treated with a crude mycelia extract of N. sphaerica gave a highest percentage of inhibition where most of the cells were died (A2) compared with the cell which treated with a crude leaf extract of C. roseus (B2).