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Ala mutation of the putative Arg40-Arg41 prodomain cleavage site does not affect processing of protein C by furin. COS-1 cells were transiently transfected with an empty vector (V) or vectors encoding furin and WT mouse protein C (mProtein C) or its prodomain PC cleavage site mutants R41A and R40A/R41A. Proteins in 24-h post-transfection conditioned media were analyzed by Western blotting using a V5-mAb. The data are representative of at least two independent experiments.
