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PAR1 inhibits the ability of furin to process protein C. A, schematic representation of PAR1 cleavage sites. B, WT protein C was co-expressed in COS-1 cells with either an empty vector or one encoding furin and/or PAR1, and the 24-h conditioned media were then analyzed by Western blotting using a V5 tag mAb. These data are representative of two independent experiments.
