Table 2. Univariate and multivariate analyses of risk factors for acquisition of fluoroquinolone or aminoglycoside resistance in addition to imipenem resistance in Pseudomonas aeruginosa.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | |
| Resistance to FQs | ||||||
| Transplantation | 1.74 | 0.80-3.78 | 0.161 | |||
| Use of corticosteroids (≥5 mg/day) or other immunosuppressive agents | 1.81 | 0.93-3.52 | 0.082 | |||
| Surgery | 0.65 | 0.35-1.21 | 0.173 | |||
| Exposure to first-generation cephalosporins | 0.60 | 0.30-1.19 | 0.143 | |||
| Exposure to second-generation cephalosporins | 0.28 | 0.08-1.01 | 0.051 | |||
| Exposure to FQs | 5.30 | 2.52-11.14 | <0.001 | 5.73 | 2.67-12.30 | <0.001 |
| Exposure to AGs | 3.92 | 1.30-11.87 | 0.016 | |||
| MBL production | 6.67 | 1.78-24.91 | 0.005 | 7.90 | 2.01-31.04 | 0.003 |
| Resistance to AGs | ||||||
| Use of anticancer drugs | 2.57 | 0.64-10.40 | 0.184 | |||
| Use of urinary catheter | 0.42 | 0.13-1.38 | 0.152 | |||
| Exposure to antipseudomonal penicillins | 0.24 | 0.05-1.14 | 0.073 | 0.16 | 0.03-0.89 | 0.036 |
| Exposure to AGs | 6.04 | 1.59-23.00 | 0.008 | 9.00 | 1.92-42.19 | 0.005 |
| MBL production | 7.35 | 1.89-28.65 | 0.004 | 8.49 | 1.87-38.52 | 0.006 |
OR, odds ratio; CI, confidence interval; FQs, fluoroquinolones; AGs, aminoglycosides; MBL, metallo-β-lactamase