Table 3.
Studies investigating DPP4 inhibition in models of renal IRI
| Study | Design | IRI | Outcome | Overall |
|---|---|---|---|---|
|
Sitagliptin Nuransoy et al. (2015) |
Healthy, female rats, 14 days, 5 mg·kg−1·day−1
pre IRI |
60 min IRI + UniNX |
↓ Oxidative stress ↑ Antioxidative enzymes ↓ Tubular damage ↔ Serum creatinine 24 h post IRI |
Tubular effects |
|
Sitagliptin Vaghasiya et al. (2011) |
Diabetic, male/female rats, 14 days, 5 mg·kg−1·day−1
pre IRI |
30 min bilateral IRI |
↓ Serum AST, creatinine, urea nitrogen 24 h post IRI ↑ Antioxidative enzymes ↓ Tubular damage |
Tubular and glomerular effects |
|
Sitagliptin Youssef et al. (2015) |
Healthy, male rats, 5 mg·kg−1
5/22 h post IRI |
30 min bilateral IRI |
↓ Serum urea, creatinine, cystatin C 24 h post IRI ↓ Tubular damage 24 h |
Tubular and glomerular effects |
|
Sitagliptin Chang et al. (2015) |
Healthy, male rats, 3 days, 300/600 mg·kg−1·day−1 post IRI |
60 min bilateral IRI |
↑ GLP‐1 and GLP‐1R ↓ Tubular damage 72 h post IRI Numerical reduction of serum creatinine 72 h post IRI |
Tubular effects |
|
Sitagliptin Chen et al. (2013) |
Healthy, male rats, 3 days, 600 mg·kg−1·day−1 post IRI | 60 min bilateral IRI |
↓ Serum creatinine 24 h and 72 h post IRI ↓ Tubular damage 24 and 72 h post IRI ↓ Inflammation/apoptosis/oxidative stress |
Tubular and glomerular effects |
|
Vildagliptin Glorie et al., 2012 |
Healthy, male rats, 1/10 mg·kg−1
i.v. 15 pre IRI |
30 min IRI + UniNX |
↓ Serum creatinine 12 and 48 h post IRI ↓ Tubular necrosis 12 h post IRI, ↔ at 48 h post IRI ↓ Inflammation/apoptosis/oxidative stress |
Tubular and glomerular effects |
| DPP4−/− rats Daniel et al. (2012) (Abstract) | DPP4−/− rats | 45 min IRI + UniNX |
↑ Serum creatinine 24 h post IRI versus wildtype ↑ Tubular damage versus wildtype ↑ Macrophage infiltration versus wildtype |
Detrimental tubular and glomerular effects |