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. 2017 May 9;174(14):2209–2224. doi: 10.1111/bph.13810

Table 2.

Effects of (A) fragment 2 and its derivatives and (B) fragment 6 and a derivative on HsaD enzymic activity and growth of mycobacteria on cholesterol as carbon source

ID Compound Structure IC50 (mM) MIC (μg·mL−1) growth on cholesterol
M. bovis BCG M. tuberculosis
2 3,5,‐dichloro‐benzenesulfonamide
(8).

chemical structure image

0.41 ± 0.02 <12.5 25
8 Benzenesulfonamide
(9).

chemical structure image

NI NI NI
24 3,5‐dichlorosulfanilamide
(10).

chemical structure image

0.16 ± 0.01 25 200
27 3,5‐dichloro‐4‐hydroxybenzenesulphonic acid
(11).

chemical structure image

0.27 ± 0.01 >200 >200
6 ethyl 3,5‐dichloro‐4‐hydroxybenzoate
(12).

chemical structure image

0.52 ± 0.02 <12.5 <12.5
32 3,5‐dichloro‐4‐hydroxybenzoic acid
(13).

chemical structure image

0.54 ± 0.01 <12.5 200

NI indicates no inhibition observed at 5 mM for inhibition of enzyme activity and no inhibition of growth at 200 μg·mL−1 as described in the Methods section. IC50 values shown as average ± SD (n = 6). See Supporting Information Table S1 for full list.