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. 2017 Jun 15;8:15337. doi: 10.1038/ncomms15337

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The schematic of proteomic work-flow. (b) The VHL alone-regulated proteins presented in both RCC4 and 786-O cells. The indicated genes were knocked down (c,e) or ectopically expressed (d,f) in RCC4/VHL (c,d) or 786/VHL (e,f) cells following by treatment with 1 μM doxorubicin for 48 h and the growth inhibition rates were detected. The indicated cells were compared to their counterpart (NC, non-specific shRNA control; EV, empty vector control) separately. Data represent means and s.d. of three independent experiments. (**P<0.01 for t-test).