Table 1.
Examples of organizations that incorporate systems biology approaches for drug discovery
| Name | Approach |
|---|---|
| Bioseek (http://www.bioseekinc.com) |
Uses systems biology approach to study primary human cell disease models |
| Beyond Genomics (http://www.beyondgenomics.com) |
Technology platform facilitates analysis of clinically relevant samples and integrates data from the gene, protein, metabolite, and clinic for biomarker and target identification |
| Cellnomica (http://www.cellnomica.com) |
Conducts novel multicellular modeling in drug discovery and development |
| Cellzome (http://www.cellzome.com) |
Proprietary functional proteomics technology for therapeutic target discovery, validation, and drug development |
| Department of Energy's Genomes to Life initiative (http://doegenomestolife.org/overview/pdf) |
The Genomes to Life roadmap (plans to design and exploit new high-throughput strategies to obtain a blueprint of how living systems function) |
| Eli Lilly Center for Systems Biology (http://www.lilly.com) |
Focuses on integration of proteomic and genomic technologies to support drug discovery efforts |
| Entelos (http://www.entelos.com) |
Biosimulation company that develops computer models of human disease using novel PhysioLab technology |
| Institute for Systems Biology (http://www.systemsbiology.org) |
Broad based program. Uses systems biology to investigate the complex interaction of biological elements that form hierarchical networks that define systems |
| Kitano Symbiotic Systems Project (http://www.symbio.jst.go.jp) |
The project aims to understand and design biological systems, thus creating a new paradigm in biology focuses on model organisms including fruit fly, yeast, and bacteria |
| Physiome Sciences (http://www.physiome.com) |
Biosimulation company that has created and develops integrated software platform for computer-based biological models applicable to drug discovery |
| SurroMed (http://www.surromed.com) |
Develops and implements biological marker discovery platform to profile biochemical components in blood and other biological samples |
Note. From “Advancing drug discovery through systems biology,” by E. Davidov et al., 2003, Drug Discov Today, 8, p. 175–183. Copyright 2014, Korea Institute of Oriental Medicine. Published by Elsevier. All rights reserved, Reproduced with permission.