Table 2.
Effect of mangiferin on antioxidant status and lipid peroxidation levels
Group¶ | GSHa | SOD† | CAT‡ | GST§ | LPO|| |
---|---|---|---|---|---|
I | 32.5 ± 2.7 | 30.6 ± 1.9 | 23.4 ± 1.5 | 25.6 ± 2.5 | 5 ± 0.51 |
II | 29.5 ± 2.1** | 26.4 ± 1.7** | 21.4 ± 1.2* | 21.6 ± 2.2** | 14 ± 0.63* |
III | 24.5 ± 1.7*** | 20.6 ± 1.9*** | 15.4 ± 1.1** | 17.6 ± 2.1** | 22 ± 0.47** |
IV | 21.5 ± 1.9*** | 17.6 ± 1.8*** | 11.4 ± 1.5*** | 14.3 ± 1.8*** | 27 ± 0.12** |
GSH content was expressed as nM of GSH/mg of protein.
SOD 1 U is the amount of enzyme required for 50% inhibition of pyrogallol auto-oxidation.
Catalase 1 U is the enzyme that consumes 1 nmole H2O2/minute.
GST 1 U represents the enzyme that conjugates 1 μmole CDNB/min.
LPO was expressed as TBA reactants (nM)/mg of protein.
¶ Statistical significance was obtained when different concentrations of mangiferin-treated groups were compared with the control group.
p < 0.05.
p < 0.01.
p < 0.001.
CAT, catalase; Group I, control group; Group II, 50 μM mangiferin group; Group III, 70 μM mangiferin group; Group IV, 90 μM mangiferin group; GSH, glutathione; GST, glutathione-S-transferase; LPO, lipid peroxidation; SOD, superoxide dismutase.