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. 2017 Jun 19;8:15863. doi: 10.1038/ncomms15863

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Time-lapse sequence showing the typical course of a spontaneously formed CDR (scale bar: 25 μm). The white arrow indicates the initiation of the CDR and the red arrow the macropinosomes (appearing as white spots) formed on CDR collapse. (b) Living cell stained for f-actin with a close-up view on a CDR wavefront showing its sub-structure of dynamic actin clusters (scale bars: full image 25 μm, close-up 5 μm). (c) Kymographs along red lines in normal (n) and tangential (t) direction to the CDR in b, highlighting the rapid actin turnover within CDR wavefronts. (d) Actin organization of a cell exhibiting two CDRs imaged with confocal fluorescence microscopy in two different z-positions (scale bar: 25 μm). (e) Close-up view of the vertically integrated intensity of the region of interest highlighted with a white rectangle in d. (f) Profile of fluorescence intensity sampled along a cut through the wavefront (white line in (e), length: 10 μm) showing the state of wavefront exterior () and wavefront interior ().

Inline graphic — (a) Time-lapse sequence showing the typical course of a spontaneously formed CDR (scale bar: 25 μm). The white arrow indicates the initiation of the CDR and the red arrow the macropinosomes (appearing as white spots) formed on CDR collapse. (b) Living cell stained for f-actin with a close-up view on a CDR wavefront showing its sub-structure of dynamic actin clusters (scale bars: full image 25 μm, close-up 5 μm). (c) Kymographs along red lines in normal (n) and tangential (t) direction to the CDR in b, highlighting the rapid actin turnover within CDR wavefronts. (d) Actin organization of a cell exhibiting two CDRs imaged with confocal fluorescence microscopy in two different z-positions (scale bar: 25 μm). (e) Close-up view of the vertically integrated intensity of the region of interest highlighted with a white rectangle in d. (f) Profile of fluorescence intensity sampled along a cut through the wavefront (white line in (e), length: 10 μm) showing the state of wavefront exterior () and wavefront interior ().