Table 1.
Effect of variables on vesicle size and entrapment efficiency
| Batches | Span 60:cholesterol | Size of empty vesicles d(0.9) nm | Size of loaded vesicles d(0.9) nm | % Entrapment efficiency |
|---|---|---|---|---|
| J1 | 1:0 | 182 ± 3.08 | 294 ± 5.53 | 52.85 ± 1.95 |
| J2 | 1:1 | 173 ± 5.53 | 327 ± 3.53 * | 55.85 ± 2.49 |
| J3 | 1:1.5 | 189 ± 3.53 | 307 ± 2.52 | 50.62 ± 1.71 † |
| J4 | 1:2 | 195 ± 2.08 | 317 ± 3.15 | 50.96 ± 1.32 |
| J5 | 1.5:1 | 211 ± 4.53 | 334 ± 4.52 † | 67.31 ± 4.89 * |
| J6 | 2:1 | 217 ± 3.00 | 427 ± 5.52 * | 71.29 ± 5.32 * |
Values are expressed as mean ± standard deviation (n = 3) followed by one-way analysis of variance with Tukey's multiple comparison test.
*
p < 0.001.
†
p < 0.05.