Table 1. Octanol/Water Partition Coefficient (logD), Protein Binding, and Stability in Human Serum (PBS as Control) of 68Ga-Labeled Hybrid Imaging Agents.
| [68Ga]Sulfo-Cy7-FSC-MG | [68Ga]Sulfo-Cy7-FSC-RGD | ||
|---|---|---|---|
| Distribution coefficient | logD (pH 7.4) | –1.9 ± 0.17 | –2.3 ± 0.16 |
| Protein binding | 1 h | 75.9 ± 1.2 | 20.5 ± 0.7 |
| 2 h | 74.1 ± 2.1 | 20.6 ± 0.9 | |
| 4 h | 73.3 ± 1.7 | 21.6 ± 1.1 | |
| Stability in PBS | 1 h | 95.1 ± 0.2 | 95.7 ± 0.1 |
| 2 h | 94.9 ± 0.4 | 94.7 ± 0.6 | |
| 4 h | 94.4 ± 0.1 | 94.4 ± 0.3 | |
| Stability in serum | 1 h | 95.5 ± 0.6 | 94.9 ± 0.8 |
| 2 h | 94.5 ± 0.5 | 94.4 ± 0.3 | |
| 4 h | 93.9 ± 0.5 | 92.6 ± 0.8 |