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. 2017 Jun 19;8:15899. doi: 10.1038/ncomms15899

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Molar fraction of PDI, p-PDI and p2-PDI versus time by LC–MS (points), following the batch addition of ATP (1 mM), PKA (0.13 μM) and λPP (0.3 μM) to a 100 μM PDI solution. The solid lines are the fits of the ODE model. The insert is a zoom at the short times. (b) Time-course CD measurements (monitored at 499 nm, optical path 1 mm) following the batch addition of ATP (2 mM) to a 200 μM PDI solution containing PKA (0.13 μM) and λPP (0.2 μM). The coloured bars at the bottom of a,b indicate the transient formation/disappearance of p2-PDI (red colour) starting from PDI (green colour). (c) Time-course CD measured after refuelling the same solution as in b with a second shot of ATP (2 mM). In this case p2-PDI accumulates.