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. 2017 Jun 20;8:15845. doi: 10.1038/ncomms15845

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Introducing local phase shifts between scatterers in the same voxel changes the intensity of the resulting speckle noise, enabling one to reduce speckle noise via averaging many different phase shifts. This leads to the detection of scatterers otherwise hidden by the speckle noise. (b) Implementation of SM-OCT on the high-resolution OCT system. DC, dispersion compensation; BS, beam splitter; L₁, lens of the conventional OCT; L₂, lenses added to create a 4f imaging system; f₁, focal length of L₁; f₂, focal length of L₂; n, refractive index of the diffuser; λ, the centre wavelength of the light source.