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In vitro ZMC1 binding to human plasma and plasma protein solutions determined by ultrafiltration and ultracentrifugation (n = 3)
| Matrix | Percentage of bound drug by
|
|
|---|---|---|
| ultrafiltration | ultracentifugation | |
| Plasma | 98.8 | 97.5 |
| Human serum albumin (4%) | 98.4 | N/D |
| Human α1-acid glycoprotein (0.1%) | 34.9 | N/D |
