Table 1.
Hemodynamic and tissue perfusion parameters of patients
| Hemodynamic parameters at H6 | Sepsis | Septic shock survivors | Septic shock non-survivors | P value |
|---|---|---|---|---|
| Number | 11 | 18 | 8 | - |
| SAPS II | 38 (30; 41) | 53 (35; 70) | 80 (53; 82) | a, <0.001 b, 0.08 |
| SOFA score | 5 (3; 6) | 9 (7; 13) | 16 (12; 17) | a, <0.001 b, <0.001 |
| Mechanical ventilation (%) | 12 | 55 | 75 | a, 0.03 b, ns |
| Norepinephrine dose (μg/kg/min) | - | 0.30 (0.13; 80) | 1.10 (0.60; 1.50) | b, 0.009 |
| MAP (mmHg) | 75 (66; 83) | 73 (68; 79) | 68 (65; 76) | a, ns b, ns |
| Cardiac index (L/min/m2) | 2.7 (2.4; 3.0) | 2.6 (2.4; 3.4) | 2.5 (2.0; 3.1) | a, ns b, ns |
| Urinary output (mL/Kg/h) | 1.0 (0.7; 2.1) | 0.9 (0.5; 1.3) | 0.4 (0.1; 0.5) | a, ns b, 0.02 |
| Lactate level (mmol/L) | 1.3 (1.0; 1.8) | 1.6 (0.9; 2.5) | 5.3 (3.0; 9.5) | a, ns b, 0.004 |
| Mottling presence, n (%) | 1 (9) | 5 (27) | 4 (50) | a, ns b, ns |
| Temperature, core (°C) | 37.7 (36.3; 38.7) | 38.1 (37.8; 39.3) | 36.8 (35.4; 37.9) | a, ns b, ns |
| Temperature, forearm skin (°C) | 30.3 (28.9; 31.7) | 30.1 (28.7; 31.6) | 29.1 (27.7; 29.9) | a, ns b, ns |
| Temperature, knee skin (°C) | 30.4 (28.9; 31.6) | 29.4 (28.3; 30.1) | 28.9 (27.1; 29.9) | a, ns b, ns |
Data are expressed as number (percentage) or median (interquartile range). Statistical analysis: a, sepsis vs. septic shock survivors; b, septic shock survivors vs. septic shock non-survivors. H6 6 h after initition of vasopressors, SOFA Sequential Organ Failure Assessment; SAPS II Simplified Acute Physiology Score; MAP mean arterial pressure; ns non significant