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. 2017 May 9;117(8):1075–1085. doi: 10.1017/S0007114517000903

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© The Authors 2017

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Metabolic profiling revealed complex changes in lipid metabolism. (a) Proportional clustering shows statistically different metabolites (n 153, P<0·05) affiliated to their main pathway. (b) Enrichment analysis revealed six significantly enriched sub-pathways. Scores underlie an enrichment of significantly different metabolites of total detected metabolites within a sub-pathway in relation to all significant metabolites to all detected metabolites. Graph shows statistically significant enriched (P<0·05) sub-pathways according to their calculated enrichment scores with indicated P values. The maximum achievable enrichment score is 3·7 (marked with max), if all detected metabolites in a sub-pathway are described as statistical significant different. For all sub-pathway enrichment scores see the online Supplementary Table S4.