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. 2017 May 9;117(8):1075–1085. doi: 10.1017/S0007114517000903

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© The Authors 2017

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Metabolic profiling revealed changes in PUFA synthesis. (a) Metabolites illustrated in the PUFA synthesis pathway with lipoxygenase (LOX) and cytochrome P450 (CYP)-derived eicosanoid classes. , , Statistically significant lower and higher metabolite levels in the high-arachidonic acid (ARA) group compared with the control group. Grey highlighted metabolites were not detected. (b) and (c) Box plots of normalised data expressed as scaled intensity of single n-3 and n-6 PUFA, respectively. , Control; , high-ARA; ARA, 20 : 4n-6; DHA, 22 : 6n-3; EPA, 20 : 5 n-3; n-3 DPA, 22 : 5 n-3; n-6 DPA, 22 : 5 n-6; 5-HEPE, 5-hydroxy-EPA; 5-HETE, 5-hydroxy-eicosatetraenoic acid; 12-HETE, 12-hydroxy-eicosatetraenoic acid; 5-KETE (5-oxo-ETE), 5-keto-eicosatetraenoic acid (5-oxo-eicosatetraenoic acid); 13/9-HODE, 13/9-hydroxy-octadecadienoic acid; 12,13-DiHOME, 12,13-dihydroxy-octadecenoic acid; 9,10-DiHOME, 9,10-dihydroxy-octadecenoic acid. * Significant difference (P<0·05) between feed groups (Welch’s two-sample t test).

Inline graphic — Metabolic profiling revealed changes in PUFA synthesis. (a) Metabolites illustrated in the PUFA synthesis pathway with lipoxygenase (LOX) and cytochrome P450 (CYP)-derived eicosanoid classes. , , Statistically significant lower and higher metabolite levels in the high-arachidonic acid (ARA) group compared with the control group. Grey highlighted metabolites were not detected. (b) and (c) Box plots of normalised data expressed as scaled intensity of single n-3 and n-6 PUFA, respectively. , Control; , high-ARA; ARA, 20 : 4n-6; DHA, 22 : 6n-3; EPA, 20 : 5 n-3; n-3 DPA, 22 : 5 n-3; n-6 DPA, 22 : 5 n-6; 5-HEPE, 5-hydroxy-EPA; 5-HETE, 5-hydroxy-eicosatetraenoic acid; 12-HETE, 12-hydroxy-eicosatetraenoic acid; 5-KETE (5-oxo-ETE), 5-keto-eicosatetraenoic acid (5-oxo-eicosatetraenoic acid); 13/9-HODE, 13/9-hydroxy-octadecadienoic acid; 12,13-DiHOME, 12,13-dihydroxy-octadecenoic acid; 9,10-DiHOME, 9,10-dihydroxy-octadecenoic acid. * Significant difference (P<0·05) between feed groups (Welch’s two-sample t test).