Table 4.
Results for re-implantation of cryopreserved tumors
| Case | Pre-implanted tumor | Cryo-medium | Cryopreserved days | Engraftment | Post-implanted tumor | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Generation | Pigment | Ki67% positive cells (%) | Generation | Tumor take rate (mouse) | Volume (mm3) | Pigment | Ki67% positive cells (%) | ||||
| 2 | X1 | None | 20.1 | Fresh | None | Success | X2 | 1/1 | 958.9 | None | 17.0 |
| F | 30 | Success | 1/1 | 189.2 | None | 15.4 | |||||
| D | Success | 1/1 | 364.1 | None | 15.0 | ||||||
| R | Success | 1/1 | 103.5 | None | 14.9 | ||||||
| 5 | X1 | None | 24.6 | Fresh | None | Success | X2 | 1/1 | 1258.0 | None | 22.8 |
| F | 15 | Success | 1/1 | 128.3 | None | 14.2 | |||||
| D | Success | 1/1 | 635.1 | None | 19.8 | ||||||
| R | Success | 1/1 | 254.3 | None | 17.3 | ||||||
| 7 | X1 | Minimal | 16.1 | Fresh | Success | X2 | 1/1 | 365.1 | Minimal | 15.9 | |
| F | 15 | Failure | 0/1 | – | – | – | |||||
| D | Success | 1/1 | 5.5 | Minimal | 15.4 | ||||||
| R | Success | 1/1 | 0.32 | Minimal | 15.7 | ||||||
| 12 | X1 | Moderate | 18.3 | Fresh | None | Success | X2 | 1/1 | 998.5 | Moderate | 20.4 |
| F | 15 | Success | 1/1 | 92.34 | Moderate | 15.6 | |||||
| D | Success | 1/1 | 686.7 | Moderate | 16.9 | ||||||
| R | Success | 1/1 | 502.1 | Moderate | 15.2 | ||||||
X 0 patient’s tumor; X 1 first-generation mice, X 2 second-generation mice, fresh direct implantation without cryopreservation, F F medium (90% fetal bovine serum/10% DMSO), D D medium (70% DMEM/20% fetal bovine serum/10% DMSO), R R medium (70% RPMI/20% fetal bovine serum/10% DMSO)