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. 2017 Jun 23;17:441. doi: 10.1186/s12885-017-3431-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Composition of a total cohort with sequential cellular lineage of hepatic carcinomas. CK19(−) HCC is the most hepatic differentiation and sequentially CK19(−) HCC scirrhous type, CK19(+) HCC, combined hepatocellular-cholangiocarcinoma(stem cell feature, classical type), intrahepatic cholangiocarcinoma (cholangiolocellualr, non-cholangiolocellular) and extrahepatic bile duct carcinoma show biliary differentiation