Fig. 1.

HSV-1 infects the trigeminal branch divisions, TG, and OB early following ocular infection. Mice (n = 6–10/group) were infected with 1000 PFU HSV-1/cornea. a Swabs were taken from cornea tear film and external nasal cavity secretions and were evaluated for infectious virus by plaque assay from 1 to 8 DPI. b-c HSV-1-specific lytic cycle gene expression RT-PCR results from 1–2 DPI (n = 3–6/group) of the ophthalmic (Opth.), maxillary (Max.), and mandibular (Mand.) division of the trigeminal nerve ganglia (TG), OB, and brain stem (BS). d-e Cxcl10 expression measured by RT-PCR at 2 DPI (n = 3–6/group). Each n value represents sample data from an individual mouse, and 1–2 DPI graphs are represented by mean ± SEM, **p < 0.005 comparing nasal to cornea swabs