Table 3.
Association of CLOCK SNPs with sleep parameters and variables related to body weight regulation
| SNPs | Adiponectin | Leptin | BMI | Sleep Duration | Sleep Quality | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs | Alleles | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | OR (SE) | P value |
| rs6820823 | A/G | −0.018 (0.02) | 0.43 | −0.017 (0.02) | 0.49 | −0.018 (0.007) | 0.010 | 0.005 (0.00) | 0.50 | 1.068 (0.07) | 0.40 |
| rs17721497 | A/T | 0.009 (0.03) | 0.76 | −0.061 (0.03) | 0.07 | −0.008 (0.009) | 0.38 | 0.007 (0.01) | 0.47 | 1.090 (0.10) | 0.41 |
| rs6820119 | A/G | −0.027 (0.03) | 0.36 | 0.0067 (0.03) | 0.84 | 0.006 (0.009) | 0.52 | −0.005 (0.01) | 0.60 | 0.962 (0.10) | 0.71 |
| rs3792603 | A/G | −0.018 (0.02) | 0.43 | −0.017 (0.02) | 0.49 | −0.018(0.007) | 0.010 | 0.005 (0.00) | 0.49 | 1.068 (0.07) | 0.40 |
| rs11932595 | A/G | −0.014 (0.04) | 0.71 | 0.018 (0.04) | 0.68 | 0.012 (0.012) | 0.32 | −0.003 (0.01) | 0.81 | 0.899 (0.13) | 0.43 |
| rs17085763 | T/C | −0.023 (0.03) | 0.45 | −0.003 (0.03) | 0.92 | 0.006 (0.009) | 0.48 | −0.005 (0.01) | 0.64 | 0.990 (0.10) | 0.93 |
| rs17085780 | C/T | 0.07 (0.05) | 0.18 | −0.006 (0.06) | 0.91 | 0.006 (0.016) | 0.70 | −0.011 (0.01) | 0.55 | 1.193 (0.19) | 0.35 |
| rs2070062 | T/G | 0.007 (0.02) | 0.77 | −0.009 (0.02) | 0.73 | 0.001 (0.007) | 0.83 | −0.027 (0.001) | 0.003 | 0.920 (0.08) | 0.32 |
| rs7684048 | T/C | −0.071 (0.04) | 0.08 | 0.014 (0.04) | 0.75 | 0.0001 (0.01) | 0.99 | 0.007 (0.01) | 0.64 | 1.030 (0.14) | 0.83 |
| rs7657206 | T/C | −0.110 (0.09) | 0.24 | 0.066 (0.10) | 0.53 | −0.010 (0.027) | 0.69 | −0.009 (0.03) | 0.77 | 1.936 (0.37) | 0.07 |
| rs11726609 | T/A | 0.018 (0.01) | 0.32 | 0.026 (0.02) | 0.21 | 0.012 (0.005) | 0.03 | −0.009 (0.00) | 0.1725 | 0.930 (0.06) | 0.27 |
| rs6853192 | T/A | −0.0005 (0.03) | 0.98 | 0.044 (0.03) | 0.22 | 0.0096 (0.010) | 0.33 | −0.027 (0.01) | 0.02 | 1.113 (0.11) | 0.34 |
Alleles listed as major/minor allele; Model adjusted for age, gender, BMI, SES, smoking status, alcohol consumption and PEA: The results of the association are listed for continuous variables as the Beta (standard error) (β (SE)) with the corresponding raw P-value. β coefficients represent the change in absolute trait values of each additional risk allele. The results of the association are listed for categorical variables as OR (standard error) (OR (SE)) with the corresponding P-value.
SES: socio economic status; BMI: body mass index; PEA; proportion of global European ancestry; The variants rs1801260, rs17085747, rs11931061 and rs12648271 were removed from the table because the software was unable to fit the regression model