Table 4.

Associations between the most common five-marker haplotype combinations in the CLOCK gene with sleep and body weight regulation related variables

		Adiponectin			Leptin			BMI			Sleep duration			Sleep quality
Haplotype	F	β	T	P*	β	T	P*	β	T	P*	β	T	P*	OR	T	P*
22,221 (GGGCA)	0.05	0.004	0.02	0.88	−0.044	1.5	0.22	−0.013	1.5	0.22	0.025	3.8	0.05	0.95	0.25	0.61
22,112 (GGTTA)	0.19	0.079	3.71	0.05	−0.025	0.30	0.57	−0.008	0.41	0.52	−0.008	0.28	0.59	0.95	0.15	0.69
11,222 (AAGCA)	0.08	−0.019	0.30	0.57	0.071	3.44	0.06	0.015	1.7	0.192	0.015	1.27	0.25	1.11	0.96	0.32
12,222(AGGCA)	0.07	0.017	0.43	0.43	0.017	0.48	0.48	0.015	3.91	0.04	−0.0005	0.003	0.95	0.96	0.31	0.57
22,222 (GGGCA)	0.60	−0.024	0.19	0.19	−0.012	0.37	0.54	−0.008	1.74	0.18	−0.010	2.1	0.14	1.02	0.16	0.68

The results of the association are listed for continuous variables as the Beta (standard error) (β (SE)) with the corresponding P-value. β coefficients represent the change in absolute trait values of each additional risk allele. The results of the association are listed for categorical variables as OR (standard error) (OR (SE)) with the corresponding P*: adjusted p-value. Model adjusted for age, gender, BMI, SES, smoking status, alcohol consumption and PEA. SES: socio economic status; BMI: body mass index; PEA; proportion of global European ancestry. F: haplotype frequency. T: T value from Wald test