CNQX-evoked currents are reduced in lamina II neurons of stg/stg mice. A, Representative whole-cell current (−60 mV) in a wt lamina II neuron evoked by bath application of CNQX (10 μm) in the presence of cylothiazide (100 μm). Bottom trace (colored), Isolated holding current (1 s bins) (see Materials and Methods). B, Same as A, but for a neuron from an stg/stg mouse. C, Same as A, but for a GAD65-positive neuron (wt mouse). D, Summary data for CNQX-evoked currents. Box-and-whisker plots indicate the median (line), 25th and 75th percentile (box), range of data within 1.5× interquartile range (whiskers), and mean (white circles). Superimposed filled circles represent individual cells. A one-way ANOVA indicated a significant difference among the three groups (F(2,32) = 16.97, p < 0.0001). ***p < 0.001 (pairwise differences). E, Summary data for AMPA-evoked currents. Box-and-whisker plots as in E.