Table 4.
Associations of newborn cord metabolites with birth weight and SSF
| Metabolite |
Afro-Caribbean | Northern European | Mexican American | Thai | Meta-analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | Q | Q test P | I2 | |
| Birth weight (g) | |||||||||||||
| 3-Hydroxybutyrate | 71.09 (22.67) | 3.37e-02 | 77.44 (24.46) | 4.50e-02 | 53.34 (21.43) | 2.29e-01 | 35.87 (16.87) | 1.92e-01 | 54.85 (10.43) | 7.85e-06 | 2.64 | 9.69e-01 | 1.11 |
| AC C10-OH/C8-DC | 106.09 (38.36) | 6.88e-02 | 105.83 (47.93) | 3.00e-01 | 91.89 (41.63) | 3.32e-01 | 71.19 (35.94) | 2.18e-01 | 91.76 (20.14) | 1.40e-04 | 0.55 | 9.92e-01 | 0.00 |
| AC C4-OH | 77.28 (28.37) | 6.88e-02 | 67.20 (32.15) | 3.35e-01 | 51.98 (29.20) | 4.75e-01 | 45.67 (21.66) | 1.92e-01 | 57.91 (13.47) | 3.07e-04 | 0.91 | 9.88e-01 | 0.00 |
| Proline | 2.37 (0.99) | 1.09e-01 | 1.46 (1.00) | 3.78e-01 | 1.27 (0.85) | 5.92e-01 | 1.76 (0.78) | 1.73e-01 | 1.69 (0.45) | 1.61e-03 | 0.78 | 9.92e-01 | 0.00 |
| Triglycerides | −2.27 (1.77) | 4.64e-01 | −4.91 (1.49) | 4.50e-02 | −2.59 (1.64) | 5.92e-01 | −7.36 (1.77) | 2.15e-03 | −4.27 (1.13) | 1.61e-03 | 5.56 | 9.69e-01 | 45.61 |
| AC C6-DC/C8-OH | 57.08 (41.17) | 4.47e-01 | 73.07 (45.81) | 3.78e-01 | 106.10 (39.03) | 2.29e-01 | 56.91 (33.88) | 3.26e-01 | 72.37 (19.63) | 1.76e-03 | 1.09 | 9.88e-01 | 0.00 |
| AC C8:1-DC | 108.26 (54.59) | 2.04e-01 | 102.97 (63.74) | 3.78e-01 | 83.64 (57.48) | 5.92e-01 | 98.04 (43.75) | 1.73e-01 | 98.24 (26.66) | 1.76e-03 | 0.10 | 9.98e-01 | 0.00 |
| Serine | 4.66 (1.50) | 3.37e-02 | 1.52 (1.36) | 5.54e-01 | 1.17 (0.96) | 6.64e-01 | 2.57 (1.02) | 1.26e-01 | 2.25 (0.66) | 4.61e-03 | 4.24 | 9.69e-01 | 22.29 |
| Glutamine/glutamic acid | 0.50 (0.57) | 6.05e-01 | 0.70 (0.70) | 5.80e-01 | 0.25 (0.72) | 9.53e-01 | 1.39 (0.49) | 9.32e-02 | 0.82 (0.30) | 3.60e-02 | 2.28 | 9.69e-01 | 0.00 |
| AC C12-OH/C10-DC | 31.17 (36.33) | 6.05e-01 | 44.80 (44.93) | 5.80e-01 | 20.11 (31.55) | 8.98e-01 | 73.18 (27.97) | 1.25e-01 | 45.12 (16.82) | 3.94e-02 | 1.78 | 9.69e-01 | 0.00 |
| Glycine | 2.61 (0.73) | 1.98e-02 | 1.28 (0.72) | 3.78e-01 | 0.32 (0.48) | 8.98e-01 | 1.08 (0.54) | 2.18e-01 | 1.22 (0.46) | 4.14e-02 | 6.96 | 9.69e-01 | 57.35 |
| AC C8:1-OH/C6:1-DC | 68.87 (58.03) | 5.23e-01 | 34.76 (57.20) | 7.69e-01 | 72.38 (55.60) | 6.64e-01 | 78.09 (41.96) | 2.64e-01 | 66.16 (25.87) | 4.75e-02 | 0.40 | 9.96e-01 | 0.00 |
| AC C20-OH/C18-DC | −36.09 (62.03) | 6.97e-01 | −16.75 (65.72) | 8.96e-01 | −28.13 (50.24) | 8.98e-01 | −155.62 (46.25) | 2.28e-02 | −66.11 (36.43) | 1.56e-01 | 5.07 | 9.69e-01 | 42.57 |
| SSF (mm) | |||||||||||||
| 3-Hydroxybutyrate | 0.1701 (0.0903) | 2.51e-01 | 0.4307 (0.1398) | 1.19e-01 | 0.1454 (0.1550) | 8.36e-01 | 0.2611 (0.1077) | 2.84e-01 | 0.2369 (0.0576) | 2.09e-03 | 2.87 | 8.31e-01 | 0.02 |
| Serine | 0.0133 (0.0059) | 1.88e-01 | 0.0126 (0.0078) | 6.47e-01 | 0.0110 (0.0069) | 6.99e-01 | 0.0125 (0.0065) | 4.73e-01 | 0.0124 (0.0033) | 5.34e-03 | 0.07 | 9.96e-01 | 0.00 |
| AC C4-OH | 0.1992 (0.1128) | 2.51e-01 | 0.3173 (0.1839) | 6.47e-01 | 0.2002 (0.2101) | 8.36e-01 | 0.2631 (0.1382) | 4.73e-01 | 0.2366 (0.0739) | 2.12e-02 | 0.37 | 9.96e-01 | 0.00 |
| AC C10-OH/C8-DC | 0.3586 (0.1529) | 1.66e-01 | 0.3605 (0.2766) | 6.82e-01 | 0.3522 (0.2990) | 7.33e-01 | 0.2800 (0.2289) | 7.99e-01 | 0.3406 (0.1077) | 2.12e-02 | 0.09 | 9.96e-01 | 0.00 |
| Proline | 0.0085 (0.0039) | 1.96e-01 | 0.0027 (0.0057) | 8.49e-01 | 0.0052 (0.0061) | 8.36e-01 | 0.0091 (0.0050) | 4.73e-01 | 0.0070 (0.0025) | 4.41e-02 | 0.99 | 9.57e-01 | 0.00 |
| AC C8:1-DC | 0.5139 (0.2165) | 1.66e-01 | 0.3805 (0.3651) | 7.31e-01 | 0.7178 (0.4122) | 6.99e-01 | 0.1050 (0.2802) | 9.36e-01 | 0.4083 (0.1451) | 4.41e-02 | 1.98 | 8.63e-01 | 0.00 |
| Triglycerides | −0.0113 (0.0070) | 2.51e-01 | −0.0207 (0.0086) | 4.37e-01 | −0.0195 (0.0119) | 6.99e-01 | −0.0566 (0.0112) | 3.46e-05 | −0.0261 (0.0098) | 5.83e-02 | 11.97 | 4.05e-01 | 76.80 |
| AC C20-OH/C18-DC | −0.2296 (0.2447) | 5.81e-01 | −0.3050 (0.3751) | 8.06e-01 | −0.3386 (0.3592) | 8.36e-01 | −1.1683 (0.2952) | 2.43e-03 | −0.5179 (0.2345) | 1.33e-01 | 6.81 | 8.31e-01 | 55.41 |
All amino acids and acylcarnitines, as well as 3-hydroxybutyrate, are measured in µmol/L. Triglycerides are measured in mg/dL. Both ancestry-specific and meta-analysis P values represent the P value after FDR adjustment.