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. 2017 May 31;16(1):581–590. doi: 10.3892/mmr.2017.6655

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — ALP and ARS staining in BMSCs after FK506-induced osteogenic differentiation. (A) ALP and ARS staining were strongest in rat BMSCs when stimulated with FK506 at the concentration of 50 nM. (B) Expression levels of osteoblastic specific genes were significantly increased at 50 nM FK506 treatment for 7 days. *P<0.05 and **P<0.01 compared with NC. Data are expressed as the mean ± standard error of the mean; n=3 per group. ALP, alkaline phosphatase; ARS, alizarin red S; d, days; NC, negative control; OCN, osteocalcin; OPN, osteopontin; Runx2, runt-related 2.