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. 2017 Apr 25;66(7):1901–1913. doi: 10.2337/db17-0029

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© 2017 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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β/α-Cell mass and β-cell proliferation in pancreas from K_ATPHI and control infants. Pancreatic tissue slides were obtained from K_ATPHI, age-matched autopsy or surgical control subjects and older control subjects and immunolabeled for insulin, glucagon, and Ki67. A: β-Cell area as the percentage of the total pancreatic area containing islet cells positive for insulin among all cells in the slide in K_ATPHI (n = 40) and age-matched control (n = 29) subjects. B: α-Cell area as the percentage of the total pancreatic area containing islet cells positive for glucagon among all cells in the slide in K_ATPHI (n = 40) and age-matched control (n = 29) subjects. C: Ratio of β-cell to α-cell area in K_ATPHI (n = 40) and age-matched control (n = 29) subjects. D: Percentage of Ki67-positive cells among insulin-positive cells in K_ATPHI (n = 40), older control pancreata (n = 5), and age-matched control pancreata (n = 29).