Figure 1.

Chronological listing of type 2 diabetes–associated loci, plotted by year of definitive publication and approximate effect size. They are named by the nearest gene, though this convention does not indicate that the causal gene has been found at the locus. Candidate loci are shown in green, loci discovered via agnostic genome-wide association approaches in blue, loci identified by exome sequencing in orange, and loci identified by whole-genome sequencing in red. TCF7L2 (shown in purple) was discovered by dense fine-mapping under a linkage signal. TBC1D4 (shown in pink) was identified by exome sequencing of a locus found to be associated with a diabetes-related quantitative trait. Gene names that are underlined denote identification in population isolates. T2D, type 2 diabetes.