Table 3.

Evidence of utility of genetic approaches in drug target identification in type 2 diabetes and related traits

Retrospective: Genetic studies have yielded associated genes that are known targets for currently marketed medications.

Prospective: Genetic studies (in Mendelian disease) have yielded target genes for which novel drugs have been developed and approved.

Genes that encode existing drug targets are enriched for variants that are associated with type 2 diabetes.

Unbiased genomic searches can uncover loci associated with drug response.