Table II.
GO analysis for the differentially expressed genes regulated by hypoxia.
| Term | Genes (n) | P-value |
|---|---|---|
| Molecular function | ||
| GO:0043167 ion binding | 333 | 7.8621E-05 |
| GO:0043169 cation binding | 329 | 8.79225E-05 |
| GO:0046872 metal ion binding | 326 | 9.99094E-05 |
| GO:0016836 hydro-lyase activity | 12 | 0.000122629 |
| GO:0017016 Ras GTPase binding | 12 | 0.001984074 |
| GO:0000287 magnesium ion binding | 46 | 0.002246305 |
| GO:0031267 small GTPase binding | 12 | 0.002642921 |
| GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | 13 | 0.002791662 |
| GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | 13 | 0.003165874 |
| GO:0051020 GTPase binding | 12 | 0.003951419 |
| GO:0046914 transition metal ion binding | 218 | 0.005063268 |
| GO:0019899 enzyme binding | 28 | 0.006555908 |
| GO:0005506 iron ion binding | 38 | 0.007222115 |
| GO:0001882 nucleoside binding | 135 | 0.009641824 |
| GO:0001883 purine nucleoside binding | 134 | 0.010743224 |
| GO:0031418 L-ascorbic acid binding | 6 | 0.011357513 |
| GO:0004725 protein tyrosine phosphatase activity | 15 | 0.011975484 |
| GO:0030554 adenyl nucleotide binding | 132 | 0.01339165 |
| GO:0003779 actin binding | 32 | 0.013513591 |
| GO:0004674 protein serine/threonine kinase activity | 43 | 0.016010492 |
| GO:0031406 carboxylic acid binding | 13 | 0.016733784 |
| GO:0004672 protein kinase activity | 56 | 0.018393253 |
| GO:0008092 cytoskeletal protein binding | 42 | 0.019021647 |
| GO:0005524 ATP binding | 123 | 0.022617503 |
| GO:0019992 diacylglycerol binding | 10 | 0.022656776 |
| GO:0019842 vitamin binding | 16 | 0.024555951 |
| GO:0015293 symporter activity | 17 | 0.02501501 |
| GO:0017076 purine nucleotide binding | 154 | 0.029861653 |
| GO:0032559 adenyl ribonucleotide binding | 123 | 0.030297935 |
| GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | 5 | 0.034869252 |
| GO:0004089 carbonate dehydratase activity | 5 | 0.034869252 |
| GO:0050662 coenzyme binding | 19 | 0.035408286 |
| GO:0004721 phosphoprotein phosphatase activity | 18 | 0.042027399 |
| GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor | 3 | 0.043728093 |
| GO:0008138 protein tyrosine/serine/threonine phosphatase activity | 7 | 0.049875355 |
| Biological process | ||
| GO:0006006 glucose metabolic process | 22 | 0.000792317 |
| GO:0055114 oxidation reduction | 70 | 0.000950229 |
| GO:0006796 phosphate metabolic process | 83 | 0.003423909 |
| GO:0006793 phosphorus metabolic process | 83 | 0.003423909 |
| GO:0044271 nitrogen compound biosynthetic process | 35 | 0.004517996 |
| GO:0007601 visual perception | 16 | 0.004646543 |
| GO:0050953 sensory perception of light stimulus | 16 | 0.00510266 |
| GO:0007242 intracellular signaling cascade | 85 | 0.006819851 |
| GO:0019318 hexose metabolic process | 22 | 0.007922216 |
| GO:0005996 monosaccharide metabolic process | 24 | 0.008183748 |
| GO:0044275 cellular carbohydrate catabolic process | 11 | 0.008669622 |
| GO:0006468 protein amino acid phosphorylation | 62 | 0.009474011 |
| GO:0006096 glycolysis | 9 | 0.010826957 |
| GO:0008015 blood circulation | 16 | 0.011053616 |
| GO:0003013 circulatory system process | 16 | 0.011053616 |
| GO:0001666 response to hypoxia | 11 | 0.013524164 |
| GO:0070482 response to oxygen levels | 11 | 0.015005602 |
| GO:0042384 cilium assembly | 6 | 0.016566907 |
| GO:0007010 cytoskeleton organization | 34 | 0.022567205 |
| GO:0051241 negative regulation of multicellular organismal process | 14 | 0.023152487 |
| GO:0030029 actin filament-based process | 21 | 0.0232384 |
| GO:0030036 actin cytoskeleton organization | 20 | 0.023432887 |
| GO:0048545 response to steroid hormone stimulus | 10 | 0.023828973 |
| GO:0019374 galactolipid metabolic process | 3 | 0.02707365 |
| GO:0006681 galactosylceramide metabolic process | 3 | 0.02707365 |
| GO:0019320 hexose catabolic process | 9 | 0.028066811 |
| GO:0006007 glucose catabolic process | 9 | 0.028066811 |
| GO:0006470 protein amino acid dephosphorylation | 15 | 0.029397775 |
| GO:0006767 water-soluble vitamin metabolic process | 7 | 0.029717956 |
| GO:0051046 regulation of secretion | 16 | 0.029739379 |
| GO:0016310 phosphorylation | 65 | 0.030184101 |
| GO:0016265 death | 49 | 0.03112936 |
| GO:0060271 cilium morphogenesis | 6 | 0.032808209 |
| GO:0009743 response to carbohydrate stimulus | 6 | 0.032808209 |
| GO:0006778 porphyrin metabolic process | 6 | 0.032808209 |
| GO:0033013 tetrapyrrole metabolic process | 6 | 0.032808209 |
| GO:0009967 positive regulation of signal transduction | 20 | 0.034149817 |
| GO:0046365 monosaccharide catabolic process | 9 | 0.034329668 |
| GO:0060341 regulation of cellular localization | 19 | 0.034742883 |
| GO:0009719 response to endogenous stimulus | 21 | 0.035172676 |
| GO:0006730 one-carbon metabolic process | 15 | 0.035666401 |
| GO:0042403 thyroid hormone metabolic process | 4 | 0.037600598 |
| GO:0046164 alcohol catabolic process | 10 | 0.03779069 |
| GO:0016311 dephosphorylation | 17 | 0.039806519 |
| GO:0006357 regulation of transcription from RNA polymerase II promoter | 56 | 0.04088076 |
| GO:0008219 cell death | 47 | 0.046075704 |
| GO:0006955 immune response | 44 | 0.047117585 |
| GO:0048660 regulation of smooth muscle cell proliferation | 5 | 0.04805859 |
| GO:0050873 brown fat cell differentiation | 6 | 0.049834676 |
| Cell component | ||
| GO:0044463 cell projection part | 23 | 0.003220028 |
| GO:0042995 cell projection | 58 | 0.003517983 |
| GO:0005886 plasma membrane | 234 | 0.004494904 |
| GO:0005576 extracellular region | 143 | 0.00502389 |
| GO:0031225 anchored to membrane | 25 | 0.008680624 |
| GO:0019898 extrinsic to membrane | 46 | 0.017185716 |
| GO:0044441 cilium part | 8 | 0.020951644 |
| GO:0042579 microbody | 14 | 0.026699591 |
| GO:0005777 peroxisome | 14 | 0.026699591 |
| GO:0044421 extracellular region part | 68 | 0.031279026 |
| GO:0045121 membrane raft | 12 | 0.031670056 |
| GO:0043005 neuron projection | 26 | 0.032261958 |
| GO:0019897 extrinsic to plasma membrane | 9 | 0.034092369 |
| GO:0005829 cytosol | 50 | 0.038894078 |
| GO:0005930 axoneme | 7 | 0.039557367 |
| GO:0005901 caveola | 6 | 0.04056632 |
| GO:0031672 A band | 4 | 0.045209466 |
| GO:0005929 cilium | 16 | 0.045846025 |
| GO:0042598 vesicular fraction | 20 | 0.046732261 |
| GO:0005741 mitochondrial outer membrane | 11 | 0.048199094 |
| GO:0030016 myofibril | 12 | 0.048557001 |
GO, Gene Ontology.