Table III.
GO analysis for the differentially expressed genes regulated by leptin and hypoxia.
| Term | Genes (n) | P-value |
|---|---|---|
| Molecular function | – | – |
| Biological process | ||
| GO:0006796 phosphate metabolic process | 87 | 0.00069201 |
| GO:0006793 phosphorus metabolic process | 87 | 0.00069201 |
| GO:0016265 death | 57 | 0.000914867 |
| GO:0006468 protein amino acid phosphorylation | 67 | 0.001122958 |
| GO:0017157 regulation of exocytosis | 9 | 0.001368273 |
| GO:0008219 cell death | 55 | 0.001517519 |
| GO:0055114 oxidation reduction | 68 | 0.002418208 |
| GO:0012501 programmed cell death | 51 | 0.002614104 |
| GO:0044271 nitrogen compound biosynthetic process | 35 | 0.004597316 |
| GO:0006915 apoptosis | 49 | 0.004983028 |
| GO:0016310 phosphorylation | 70 | 0.005034959 |
| GO:0003016 respiratory system process | 4 | 0.005961782 |
| GO:0009743 response to carbohydrate stimulus | 7 | 0.008246776 |
| GO:0006006 glucose metabolic process | 19 | 0.009614291 |
| GO:0051241 negative regulation of multicellular organismal process | 15 | 0.010348645 |
| GO:0007601 visual perception | 15 | 0.011259001 |
| GO:0032940 secretion by cell | 23 | 0.011798862 |
| GO:0050953 sensory perception of light stimulus | 15 | 0.012230633 |
| GO:0046903 secretion | 26 | 0.013035463 |
| GO:0001666 response to hypoxia | 11 | 0.013616099 |
| GO:0070482 response to oxygen levels | 11 | 0.015106629 |
| GO:0009746 response to hexose stimulus | 6 | 0.016635896 |
| GO:0001974 blood vessel remodeling | 6 | 0.016635896 |
| GO:0009749 response to glucose stimulus | 6 | 0.016635896 |
| GO:0034284 response to monosaccharide stimulus | 6 | 0.016635896 |
| GO:0006730 one-carbon metabolic process | 16 | 0.01753354 |
| GO:0009719 response to endogenous stimulus | 22 | 0.019740633 |
| GO:0048608 reproductive structure development | 17 | 0.020659779 |
| GO:0048545 response to steroid hormone stimulus | 10 | 0.023972008 |
| GO:0003013 circulatory system process | 15 | 0.024166653 |
| GO:0008015 blood circulation | 15 | 0.024166653 |
| GO:0001775 cell activation | 27 | 0.025299039 |
| GO:0007242 intracellular signaling cascade | 81 | 0.02535934 |
| GO:0006865 amino acid transport | 11 | 0.026707116 |
| GO:0006681 galactosylceramide metabolic process | 3 | 0.027127455 |
| GO:0019374 galactolipid metabolic process | 3 | 0.027127455 |
| GO:0005996 monosaccharide metabolic process | 22 | 0.028503233 |
| GO:0019318 hexose metabolic process | 20 | 0.029456322 |
| GO:0006470 protein amino acid dephosphorylation | 15 | 0.029624933 |
| GO:0045944 positive regulation of transcription from RNA polymerase II promoter | 36 | 0.030944318 |
| GO:0006778 porphyrin metabolic process | 6 | 0.032936937 |
| GO:0033013 tetrapyrrole metabolic process | 6 | 0.032936937 |
| GO:0003006 reproductive developmental process | 28 | 0.033137813 |
| GO:0003001 generation of a signal involved in cell-cell signaling | 12 | 0.033562678 |
| GO:0009967 positive regulation of signal transduction | 20 | 0.034460687 |
| GO:0046324 regulation of glucose import | 5 | 0.040773001 |
| GO:0006357 regulation of transcription from RNA polymerase II promoter | 56 | 0.041404785 |
| GO:0045893 positive regulation of transcription, DNA-dependent | 40 | 0.041795439 |
| GO:0006979 response to oxidative stress | 12 | 0.041889132 |
| GO:0051254 positive regulation of RNA metabolic process | 40 | 0.045730238 |
| GO:0009220 pyrimidine ribonucleotide biosynthetic process | 4 | 0.047696549 |
| GO:0009218 pyrimidine ribonucleotide metabolic process | 4 | 0.047696549 |
| GO:0010827 regulation of glucose transport | 5 | 0.048213767 |
| GO:0042398 cellular amino acid derivative biosynthetic process | 8 | 0.049928789 |
| Cell component | ||
| GO:0005576 extracellular region | 145 | 0.002250808 |
| GO:0044463 cell projection part | 23 | 0.003001467 |
| GO:0005777 peroxisome | 16 | 0.00482117 |
| GO:0042579 microbody | 16 | 0.00482117 |
| GO:0042995 cell projection | 55 | 0.011330557 |
| GO:0045121 membrane raft | 13 | 0.013007776 |
| GO:0031225 anchored to membrane | 24 | 0.015194373 |
| GO:0005886 plasma membrane | 227 | 0.016114278 |
| GO:0008021 synaptic vesicle | 11 | 0.017112432 |
| GO:0044456 synapse part | 24 | 0.019656437 |
| GO:0033267 axon part | 6 | 0.025413 |
| GO:0044421 extracellular region part | 68 | 0.028509841 |
| GO:0019898 extrinsic to membrane | 44 | 0.035509102 |
| GO:0005730 nucleolus | 31 | 0.035643165 |
| GO:0043232 intracellular non-membrane-bounded organelle | 152 | 0.036036538 |
| GO:0043228 non-membrane-bounded organelle | 152 | 0.036036538 |
GO, Gene Ontology.