Table IV.
Pathway analysis of the differentially expressed genes regulated by leptin, hypoxia and the two in combination.
| KEGG ID | Term | n | P-value |
|---|---|---|---|
| Leptin-treated | |||
| mmu04360 | Axon guidance | 3 | 0.029392665 |
| Hypoxia-treated | |||
| mmu04062 | Chemokine signaling pathway | 28 | 0.00014053 |
| mmu00500 | Starch and sucrose metabolism | 10 | 0.000638251 |
| mmu00910 | Nitrogen metabolism | 7 | 0.004127542 |
| mmu00052 | Galactose metabolism | 7 | 0.009539235 |
| mmu04510 | Focal adhesion | 24 | 0.010772098 |
| mmu00380 | Tryptophan metabolism | 8 | 0.019533919 |
| mmu04360 | Axon guidance | 17 | 0.020000767 |
| mmu00620 | Pyruvate metabolism | 8 | 0.022185656 |
| mmu00330 | Arginine and proline metabolism | 9 | 0.0297123 |
| mmu04010 | MAPK signaling pathway | 28 | 0.029963278 |
| mmu04370 | VEGF signaling pathway | 11 | 0.03808443 |
| mmu00010 | Glycolysis/gluconeogenesis | 10 | 0.046234215 |
| Leptin and hypoxia-treated | |||
| mmu00910 | Nitrogen metabolism | 7 | 0.004076684 |
| mmu04510 | Focal adhesion | 25 | 0.005345589 |
| mmu04062 | Chemokine signaling pathway | 23 | 0.007744979 |
| mmu00330 | Arginine and proline metabolism | 10 | 0.010268331 |
| mmu00500 | Starch and sucrose metabolism | 8 | 0.010980612 |
| mmu00620 | Pyruvate metabolism | 8 | 0.021915205 |
| mmu04630 | JAK-STAT signaling pathway | 18 | 0.035405855 |
| mmu04370 | VEGF signaling pathway | 11 | 0.037534097 |
| mmu04010 | MAPK signaling pathway | 27 | 0.047450835 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; VEGF, vascular endothelial growth factor; JAK, Janus kinase; STAT, signal transducer and activator of transcription.