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Summary of DLTs
| Dose level, cells per kg | Type | Rate, n/n (%) |
|---|---|---|
| Non-flu/cy lymphodepletion | ||
| 0.5 × 106 | Grade 4 encephalopathy | 1/7 (14) |
| 1.0 × 106 | Grade 4 hydrocephalus | 1/11 (9) |
| 5.0 × 106 | — | 0/5 (0) |
| 10.0 × 106 | Grade 3 left ventricular dysfunction; | 2/5 (40) |
| Grade 3 seizure | ||
| Prescribed lymphodepletion with flu/cy | ||
| 0.5 × 106 | — | 0/6 |
| 1.0 × 106 | Grade 4 encephalopathy | 1/6 (17) |
| 5.0 × 106 | Grade 4 seizure (flu/cy); | 2/2 (100) |
| Grade 3 encephalopathy (flu/cy) |
