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. 2017 May 9;16(1):101–108. doi: 10.3892/mmr.2017.6554

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of DNR+Bor on ΔΨm and the expression of the Bcl-2 family proteins in Jurkat and Molt-4 cells. (A) Jurkat and (B) Molt-4 cells were treated with Bor with or without DNR for 24 h. The ΔΨm was determined using rhodamine123/propidium iodide double staining with flow cytometry. (C) Jurkat and (D) Molt-4 cells were treated with Bor and DNR for 6, 12 and 24 h, and total cellular extracts were subjected to western blot assays for the indicated proteins. Each experiment was performed at least 3 times independently. *P<0.05, compared with Bor or DNR treatment alone. ΔΨm, mitochondrial membrane potential; Bor, bortezomib; DNR, daunorubincin; Bcl-2, B-cell lymphoma 2; Bim, Bcl-2-interacting mediator of cell death; Bcl-2-xl, Bcl-2 extra large.