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. 2017 May 26;16(1):680–686. doi: 10.3892/mmr.2017.6637

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Metformin treatment upregulates the expression of LC3 in the liver of HFD-induced obese mice. (A) Microphotographs of liver tissues from mice in the normal chow diet, high fat diet and high fat diet+metformin groups following immunohistochemical staining of LC3. (B) Quantitative analysis of LC3-positive regions in the liver tissue sections. (C) mRNA levels of LC3 in the liver, measured using reverse transcription-quantitative polymerase chain reaction analysis and normalized to glyceraldehyde-3-phosphate dehydrogenase. Data are presented as the mean ± standard error of the mean **P<0.01; ***P<0.001. LC3, microtubule-associated protein 1 light chain 3.