Fig. 2.

Amino acid sequence alignment of arrestins indicating extensions, insertions, deletions, and functional domains among the arrestin clade. Domains depicted include the N- and C- terminal arms, Motif I-IV, NES, three NLS, SH3 domain, four PPxY motifs, clathrin binding domain (CBD), and the middle, C, and Lariat loops. The analysis was performed using ClustalW multiple alignment analysis implemented in BioEdit 7.2.5. Amino acids are colored according to their chemical properties, and conserved consensus resides are colored filled.