Figure 2.

Axonal retraction by rod photoreceptors after 2 hours of detachment. (A) The normal retina, labeled for synaptic membrane protein (SV2, green) and nuclei (stained with PI, red). SV2 label is present in the OPL and IPL. (B) Two hours after detachment SV2-immunolabel appears in the ONL. This eye received a subretinal injection of 1 mM fasudil during creation of the detachment. SV2-labeled spots (white arrows) in the ONL indicate axonal retraction. Other retinal layers appear normal. INL, inner nuclear layer; GCL, ganglion cell layer.