Table 3.

Prevalence of radiographic hand OA in the general population (Framingham cohort study) and in the METAFIB-OA study by age

Age groups (years)	Framingham total population (n=1508)	METAFIB cohort (n=301)	METAFIB HIV-1+ MetS+ (n=152)	METAFIB HIV-1+ MetS− (n=149)	METAFIB vs Framingham	METAFIB cases vs Framingham	METAFIB controls vs Framingham
Men+women (45–64)	39.3	55.5	64.5	46.3	<0.0001	<0.0001	0.09
Men	n=641	n=265	n=134	n=131
45–49	10.3	28.6	32.1	25.7	0.004	0.006	0.03
50–54	31.9	50.0	57.1	41.5	0.003	0.001	0.23
55–59	43.9	68.6	80.6	55.9	0.0004	<0.0001	0.20
60–64	56.4	88.1	100	76.2	0.0002	0.0001	0.08
All ages (45–64)	38.7	55.8	64.9	46.6	<0.0001	<0.0001	0.09
Women	n=867	n=36	n=18	n=18
45–49	13.5	38.5	50.0	20.0	0.02	0.006	0.68
50–54	26.0	46.7	57.1	37.5	0.08	0.07	0.47
55–59	45.8	100	100	100	0.005	0.06	0.03
60–64	63.2	0	0	0	0.19	NA	0.19
All ages (45–64)	39.7	52.8	61.1	44.4	0.12	0.07	0.68

Radiographic hand OA definition was presence of ≥1 affected joint with KL score ≥2.

KL, Kellgren-Lawrence score; METAFIB, Metabolic Syndrome and Fibrosis; MetS+, presence of metabolic syndrome; MetS−, absence of metabolic syndrome; OA, osteoarthritis.