Table 1. Characteristics of patients presenting with stage IV NSCLC.
| Squamous | Nonsquamous | All Patients | |
|---|---|---|---|
| Characteristics | n = 436 | n = 1,578 | N = 2,014 |
| Sex, male | 280 (64.2) | 829 (52.5) | 1,109 (55.1) |
| Age at index date, mean (SD) | 69.6 (9.3) | 66.8 (10.2) | 67.4 (10.1) |
| Range | 31–84 | 28–85 | 28–85 |
| Age at index date | |||
| <45 | 4 (0.9) | 30 (1.9) | 34 (1.7) |
| 45–54 | 22 (5.1) | 150 (9.5) | 172 (8.5) |
| 55–64 | 92 (21.1) | 444 (28.1) | 536 (26.6) |
| 65–74 | 170 (39.0) | 555 (35.2) | 725 (36.0) |
| ≥75 | 148 (33.9) | 399 (25.3) | 547 (27.2) |
| Race | |||
| Caucasian | 280 (64.2) | 980 (62.1) | 1,260 (62.6) |
| Black | 32 (7.3) | 135 (8.6) | 167 (8.3) |
| Asian | 4 (0.9) | 33 (2.1) | 37 (1.8) |
| Unknown | 120 (27.5) | 430 (27.3) | 550 (27.3) |
| History of smoking* | 394 (90.4) | 1,352 (85.7) | 1,746 (86.7) |
| BMI at index date, mean (SD)† | 26.1 (5.9) | 26.0 (5.5) | 26.0 (5.6) |
| Range | 14–53 | 12–51 | 12–53 |
| Geographic region‡ | |||
| Midwest | 99 (22.7) | 342 (21.7) | 441 (21.9) |
| Northeast | 98 (22.5) | 375 (23.8) | 473 (23.5) |
| South | 175 (40.1) | 585 (37.1) | 760 (37.7) |
| Unknown | 5 (1.2) | 24 (1.5) | 29 (1.4) |
| West | 59 (13.5) | 252 (16.0) | 311 (15.4) |
| EGFR | |||
| Negative | 67 (15.4) | 1,049 (66.5) | 1,116 (55.4) |
| Unknown | 1 (0.2) | 69 (4.4) | 70 (3.5) |
| Not tested | 368 (84.4) | 460 (29.2) | 828 (41.1) |
| ALK | |||
| Negative | 65 (14.9) | 1,002 (63.5) | 1,067 (53.0) |
| Unknown | 3 (0.7) | 89 (5.6) | 92 (4.6) |
| Not tested | 368 (84.4) | 487 (30.9) | 855 (42.5) |
| First-line induction therapy only | 433 (99.3) | 1246 (79.0) | 1679 (83.4) |
| First-line induction followed by continuation maintenance therapy | 3 (0.7) | 332 (21.0) | 335 (16.6) |
| Received second-line therapy | 169 (38.8) | 670 (42.5) | 839 (41.7) |
| Received third-line therapy | 92 (21.1) | 346 (21.9) | 438 (21.7) |
Note: Data are n (%) unless otherwise indicated.
Abbreviations: BMI, body mass index; NSCLC, non-small cell lung cancer.
*Smoking history data were missing for 17 (4%) and 56 (4%) patients in squamous and nonsquamous cohorts, respectively.
†BMI data were missing for 11 (3%) and 43 (3%) patients in squamous and nonsquamous cohorts, respectively.
‡Geographic region data were missing for 29 (1.4%) overall.