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Lipo-PGE1 strongly inhibits collagen synthesis in HDFs. Furthermore, an ERK- and Ets-1-dependent pathway is involved in Lipo-PGE1-inhibited collagen production. Lipo-PGE1 can be modulated to down-regulate collagen synthesis in human HDFs and may provide a therapeutic approach to inhibit fibrosis and its roles in the pathogenesis of skin disorders.
